Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice
时间:2020-06-11 17:09:56
Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice

作 者:Canhong Wang, Shuai Wang, Deqian Peng, Zhangxin Yu, Peng Guo*, Jianhe Wei*
影响因子: 1.71
刊物名称: Biol. Pharm. Bull.
出版年份: 2019
卷: 42  期: 7   页码:1112-1119

文章摘要 :

       Agarwood is used to treat gastrointestinal diseases. Although our previous studies demonstrated that
agarwood ethanol extract produced by the whole-tree agarwood-inducing technique (WTAAE) improves
intestinal peristalsis, the intestinal protective effect of WTAAE remains unclear. This study aimed to evalu
ate the protective effect of WTAAE on the intestinal injury induced by flfluorouracil (5-FU) and explore its
potential mechanism. Institute of Cancer Research (ICR) mice were given agarwood ethanol extracts (AAEs)
(details in materials part), including WTAAE (0.71, 1.42 and 2.84 g/kg), wild agarwood ethanol extract
(WAAE) and burning-chisel-drilling agarwood ethanol extract (FBAAE) (2.84 g/kg). A colon injury model
was induced by 5-FU. After 14 d of treatment, the histopathology and biochemical and molecular parameters
were measured. Our results indicated that WTAAE enhanced the intestinal advancing rate and alleviated the
severity of colon injury similar the WAAE and better than FBAAE. Simultaneously, WTAAE reduced the
nitric oxide (NO) concentration and increased the glutathione (GSH) and superoxide dismutase (SOD) levels.
WTAAE also reduced the levels of interleukin-17 (IL-17) and IL-33 and elevated the level of IL-10. Fur
thermore, WTAAE upregulated the mRNA expression of the nuclear factor-E2-related factor 2–antioxidant
response element (Nrf2–ARE) pathway and downregulated the mRNA levels of the nuclear factor-kappaB
(NF-κB) pathway. WTAAE had a mitigating effect on intestinal damage, suggesting that it could be used as
an intestinal protective and adjuvant therapy drug for intestinal injury induced by chemical drugs.