New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective e
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New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells

作 者:Deli Chen, Jing Qiao, Zhaocui Sun, Yangyang Liu, Zhonghao Sun, Nailiang Zhu, Xudong Xu, Junshan Yang, Guoxu Ma*
影响因子: 2.43
刊物名称: Fitoterapia
出版年份: 2019
卷: 132  期:     页码: 46-52

文章摘要 :

Seven new naphthoquinone derivatives, named eleutherins A-G (1–7), were isolated from the edible bulbs of
Eleutherine americana (Hong-Cong), which belongs to the Iridaceae family. Their structures were elucidated on
the basis of spectroscopic analysis including high-resolution-electron spray ionization-mass spectrometry (HR
ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) techniques. The absolute confifigurations of com
pounds 1–4 were determined by experimental and calculated data. Additionally, a hypothetical biosynthetic
pathway of 1–7 was postulated. All the isolates were evaluated for their protective effffect against the injury of
human umbilical vein endothelial cells (HUVECs) in vitro. Eleutherins A and B (1–2) showed a potential pro
tective effffect on microvessels.